Individuals used the key ingredients in Xenadrine with diet and exercise for 18 weeks and were remunerated. Average weight loss with key ingredients was approximately 21 lbs. vs. 2lbs. for placebo in one 12-week study, and an average of approximately 17 lbs. vs. 2 lbs. in one 8-week study. All groups followed a calorie-reduced diet. Read the entire label.